COVID-19及其对肝胆系统的影响:一篇文献综述
Sariya Khan1, Jumana Hussain Timraz2, Nourah A Al Ghamdi3
1General Medicine and Surgery, Batterjee Medical College, Jeddah, SAU.
Cureus
|April 7, 2025
概括
COVID-19可能会导致肝损伤,肝酶水平升高. 患有慢性肝病 (CLD) 的患者面临更糟糕的结果和减少疫苗的有效性,突出显示他们对SARS-CoV-2感染的脆弱性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- COVID-19呈现出广泛的临床谱,新出现的证据表明肝胆系统参与.
- 肝酶升高是COVID-19患者肝损伤的常见指标.
- SARS-CoV-2利用肝脏中的血管酶转化酶2受体进入,可能通过缺氧和细胞因子风暴导致损伤.
研究的目的:
- 审查有关COVID-19对肝脏和慢性肝病患者影响的现有文献.
- 为了研究SARS-CoV-2引起的肝损伤的机制.
- 评估COVID-19的CLD患者的结果和接种疫苗的反应.
主要方法:
- 在2024年之前发表的研究的文献综述.
- 搜索的数据库包括PubMed,谷歌学者,斯普林格和BMC图书馆.
- 关键词: "COVID-19", "肝脏", "SARS-CoV-2", "慢性肝脏疾病". 这是一个很好的例子.
主要成果:
- 在COVID-19中常见的肝酶升高包括AST,ALT和ALP,与疾病严重程度相关.
- 慢性肝病和肝细胞癌患者的COVID-19结果较差,包括更高的ICU入院率和死亡率.
- 接种COVID-19疫苗往往会在CLD和肝移植接受者中产生低于最佳的抗体反应.
结论:
- SARS-CoV-2 可以通过直接的病毒效应,免疫反应和全身缺氧引起肝损伤.
- 患有慢性肝病的人特别容易患上严重的COVID-19疾病.
- 需要进一步的研究,以了解和减轻与COVID-19相关的风险肝病患者.
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