在怀孕期间严重,不受控制的:基于人口的病例控制研究.
Bryn Kemp1, Andrew Kelso2, David Williams3
1Maternity Department, Royal Berkshire Hospitals NHS Foundation Trust, Reading, RG1 5AN, UK.
NIHR open research
|April 7, 2025
概括
怀孕期间患有严重的妇女面临更高的风险,特别是那些事先因而住院的妇女. 早期规划和专家护理对于在怀孕期间治疗的更好结果至关重要.
科学领域:
- 神经学 神经学
- 产科 产科 产科 产科 产科
- 公共卫生 公共卫生
背景情况:
- 是一种常见的严重的神经疾病在怀孕期间,影响1%的英国人口.
- 在怀孕期间比较严重的,不受控制的与得到良好控制的的结果至关重要.
研究的目的:
- 为了比较妊娠中严重,不受控制的的特征,管理和结果,与得到良好控制的.
- 确定与严重和不良妊娠结果相关的危险因素.
主要方法:
- 一项基于人口的病例控制研究,使用英国产科监测系统 (UKOSS).
- 定义的严重是因为而入院,服用≥3种抗药物或因而死亡.
- 使用多变量逻辑回归比较了94例病例和186例对照之间的妊娠前控制和结果.
主要成果:
- 患有严重的妇女在前一年更有可能被录取治疗发作 (aOR=7.38),并且最近有发作 (aOR=5.86).
- 严重病例的早产 (在37周之前) 的风险明显更高 (aOR=7.61).
结论:
- 在怀孕前一年入院治疗发作表明严重和早产的风险更高.
- 优先考虑高风险妇女进行怀孕计划讨论和怀孕期间专家审查.
- 临床医生必须强调所有患有的妇女的怀孕规划和避孕措施.
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