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Updated: Jun 14, 2026

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
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Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

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一个预训练过的变压器模型,用于从连续葡萄糖监测数据中解码单个葡萄糖动态

Yurun Lu1,2, Dan Liu3, Zhongming Liang4,5

  • 1Center for Excellence in Mathematical Sciences, National Center for Mathematics and Interdisciplinary Sciences, Hua Loo-Keng Center for Mathematical Sciences, Key Laboratory of Management, Decision and Information System, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.

National science review
|April 7, 2025
PubMed
概括

一个新的深度学习模型,CGMformer,使用连续血糖监测 (CGM) 数据准确预测糖尿病及其并发症. 这种先进的AI工具有助于早期发现糖尿病,并为更好的糖尿病管理提供个性化的生活方式建议.

关键词:
不断监测葡萄糖的情况.糖尿病 糖尿病患者 糖尿病患者葡萄糖的动力学预先训练的模型模型.

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相关概念视频

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and 'exit' via the...
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...