针对结肠癌干细胞的创新治疗方法:过渡冷大气等离子体
Abolfazl Soulat1, Taghi Mohsenpour1, Leila Roshangar2
1Department of Atomic and Molecular Physics, Faculty of Sciences, University of Mazandaran, 4741613534 Babolsar, Iran.
ACS omega
|April 7, 2025
概括
过渡冷大气等离子体 (TCAP) 有效地向结肠癌干细胞 (CCSCs),降低活力并诱导亡. 气和直接TCAP应用显示了癌症治疗中最有前途的结果.
科学领域:
- 血医学是一种血医学.
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 过渡冷大气等离子体 (TCAP) 是一种用于远程等离子体生成的新技术,包括非热电离气体混合物.
- 由于其潜在的生物医学应用,特别是癌症治疗,TCAP引起了大量的兴趣.
- 结肠癌干细胞 (CCSCs) 对瘤生长和复发至关重要,使其成为关键的治疗点.
研究的目的:
- 评估TCAP在向结肠癌干细胞 (CCSCs) 的有效性.
- 评估TCAP对CCSC增殖,亡,炎症反应和生存的影响.
- 为了比较直接与间接的TCAP应用和气与气之间的影响.
主要方法:
- 使用气和气生成TCAP,并直接应用于CCSCs (3分钟和5分钟) 或间接通过在细胞播种之前处理Matrigel.
- 进行了体外试验测试,以测量CCSC的活力,亡 (Bax/Bcl-2比率),炎症标志物 (IL-6,IL-8) 和增殖 (Ki-67).
- 使用统计分析来确定观察到的影响的意义.
主要成果:
- 暴露于TCAP显著降低了CCSC的生存能力,直接的应用显示出最大的影响.
- 在TCAP治疗组中显著诱导了细胞亡,由细胞结构增加和更高的Bax/Bcl-2比率证明.
- 炎症标志物 (IL-6,IL-8) 和扩散 (Ki-67) 显著降低,特别是在直接TCAP.
结论:
- TCAP,特别是在使用和直接应用时,显示出作为对结肠癌干细胞的治疗策略的巨大潜力.
- 这些发现为TCAP的机制提供了洞察力,包括诱导亡和减少扩散和炎症.
- TCAP代表了针对性癌症干细胞治疗的有前途的新方法.
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