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开发一种多相 perfusion 模型,用于仿生缩小阶密度瘤

Mohammad Mehedi Hasan Akash1, Nilotpal Chakraborty2, Jiyan Mohammad3,4

  • 1Department of Mechanical Engineering, South Dakota State University, Brookings, SD 57007, USA.

Experimental and computational multiphase flow
|April 7, 2025
PubMed
概括

这项研究模拟了血输送到固体瘤中的模式,揭示了更大的窗户开口可以增强瘤血吸收. 瘤血输液随着扩散距离的减少而减少,这对于药物输送策略至关重要.

关键词:
生物识别分析生物识别分析计算建模计算建模多相模拟的多相模拟血 perfusion 透 透 透 透 透 透 透 透固体瘤是一个固体瘤.

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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