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Updated: May 15, 2025

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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蛋白向性氧化 (Oxaliplatin) ((iv) 含有STING激动剂的前药物

Martijn Dijkstra1,2, Michael Gutmann3, Mathias Gradl3

  • 1University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry Waehringer Str. 42 1090 Vienna Austria christian.kowol@univie.ac.at.

Inorganic chemistry frontiers
|April 7, 2025
PubMed
概括

新的 () 复合物将化疗与免疫刺激结合起来. 虽然没有协同作用,但这些化合物对有针对性的癌症治疗有望实现,并减少副作用.

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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