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慢性病中的瘤标志物升高:一项回顾性研究
Liuxia You1, Zhongying Xu2, Qiaoling Liu1
1Department of Clinical Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
PeerJ
|April 7, 2025
概括
在慢性病 (CKD) 患者中观察到高瘤标记物,如前胃素释放 (proGRP) 和人体外皮膜蛋白4 (HE4). 这些标志物显示出早期检测功能障碍的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 慢性病 (CKD) 在全球范围内影响着大量人口.
- 早期发现功能障碍对于有效管理和改善患者的治疗结果至关重要.
- 瘤标志物越来越多地被用于非瘤应用.
研究的目的:
- 为了比较患有CKD的患者和健康个体的瘤标志物水平.
- 识别潜在的瘤标志物,用于监测早期功能障碍.
- 为了研究瘤标志物和CKD分期之间的相关性.
主要方法:
- 522名参与者的回顾性研究 (172名CKD患者,350名对照).
- 根据估计的淋巴细胞过率 (eGFR) 将CKD患者分类为阶段 (CKD1-5).
- 血肌的分析,一般临床数据和各种瘤生物标志物,包括CA125,CA15-3,CA19-9,proGRP,HE4,CEA和NSE.
主要成果:
- 与对照组相比,CKD患者中发现了CEA,CA125,CA15-3,CA19-9,NSE,proGRP和HE4的升高水平 (p <0.05).
- 这些标志物即使在正常血清肌素的CKD患者中仍然升高.
- 在早期功能缺陷方面,ProGRP和HE4具有很高的预测值 (AUC分别为0.736和0.931).
- HE4和proGRP显示与CKD阶段的正相关性 (分别r=0.623和r=0.712).
结论:
- 患有CKD的患者表现出几种瘤标志物的较高水平.
- 瘤标志物,特别是proGRP和HE4,显示出作为早期诊断功能障碍的指标的希望.
- 需要进一步的研究来验证这些发现并探索临床应用.
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