预测前列腺和临床意义上的前列腺癌中的荷尔蒙生物标志物:一项前性研究
Anil Eker1, Mahmut Cinar1, Muhammet Halil Dagasan1
1Department of Urology, Health Sciences University, İzmir City Hospital, 35540 Izmir, Turkey.
Archivos espanoles de urologia
|April 7, 2025
概括
脱乙硫酸 (DHEAS) 和密度 (TTEd) 在预测前列腺癌 (PCa) 和临床显著的PCa (csPCa) 中表现有前途. 较低的DHEAS水平与PCa风险增加相关,这表明其作为诊断标记物的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 前列腺癌 (PCa) 是男性全球领先的癌症.
- 前列腺特异性抗原 (PSA) 缺乏用于PCa诊断的特异性.
- 使用PSA密度和MRI等额外的标志物,但需要新的生物标志物.
研究的目的:
- 为了评估下丘脑-垂体轴激素和上腺素的PCa预测.
- 评估这些标志物在确定临床显著PCa (csPCa) 中的作用.
主要方法:
- 对464名接受前列腺活检的男性进行前性队列研究.
- 对PSA,丸激素 (TTE),LH,FSH,雌激素 (EST),益生素 (PRL),丸激素密度 (TTEd),PSA密度 (PSAd) 和脱二二酸盐 (DHEAS) 的预剖析血清水平的分析.
- 分类为良性,PCa和csPCa组.
主要成果:
- 在PCa患者中发现了较低的DHEAS和较高的TTEd和PSAd水平.
- 在csPCa患者中,DHEAS水平显著降低.
- 在65岁以上的男性中,低DHEAS水平与csPCa有关.
结论:
- 仅仅是血清PSA不足以进行PCa诊断.
- DHEAS和TTEd是PCa和csPCa的有价值的预测因素.
- 降低DHEAS可能表明PCa风险较高,需要进一步调查.
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