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Updated: May 15, 2025

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
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用心肌细胞丰富的USP20通过准STAT3脱化来改善病态心脏缩

Lingfeng Zhong1,2,3, Shanshan Dai4, Fan Yu1,2,3

  • 1Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|April 7, 2025
PubMed
概括

脱乌比基化酶-特定于乌比基的蛋白酶20 (USP20) 通过调节信号转换器和转录3 (STAT3) 激活器来保护心脏缩. 缺少USP20会使心脏膨胀恶化,而过度表达会减轻心脏膨胀,从而揭示出治疗目标.

关键词:
心脏过度缩小的心脏过度缩小这是心肌细胞 (cardiomyocyte).没有除化酶的酶.信号传感器和转录的激活器 3 3乌比奎丁特异性蛋白酶 20 的存在.

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