牙周炎作为结直肠癌的危险因素:系统性审查和元分析
R-E Espejo-Carrera1, T-M Honores-Solano, T-V Ulloa-Cueva
13145 America Sur Avenue Monserrate Neighborhood Trujillo, 13008, Peru respejo.carrera@gmail.com.
Medicina oral, patologia oral y cirugia bucal
|April 7, 2025
概括
牙周炎整体而言并不是结直肠癌 (CRC) 的重要危险因素. 然而,这次系统性审查发现,牙周炎可能会增加男性的CRC风险,证据的确定性中等.
科学领域:
- 口腔健康 口腔健康
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 之前关于牙周炎和结直肠癌 (CRC) 的研究缺乏足够的统计能力.
- 为了澄清这种关联,进行了系统审查和元分析.
研究的目的:
- 确定牙周炎是否是结直肠癌 (CRC) 的风险因素.
主要方法:
- 在五个数据库的系统搜索中,确定了到2024年7月3日的队列和病例控制研究.
- 使用纽卡斯尔-太华尺度 (NOS) 评估偏差风险,并通过GRADE系统确定证据确定性.
- 分析综合了来自8项包含的队列研究的数据.
主要成果:
- 总的来说,牙周炎没有被发现是CRC的危险因素 (RR=1.34;95% CI:0.96-1.89).
- 亚组分析显示,患有牙周炎的男性中CRC风险增加了32% (RR=1.32;95% CI:1.16-1.50).
- 总体关联的证据确定性非常低,而对于男性来说,证据的确定性是中等的.
结论:
- 根据目前的证据,牙周炎不被认为是结直肠癌 (CRC) 的风险因素,确定性很低.
- 然而,牙周炎被确定为CRC的风险因素,特别是在男性中,证据的确定性中等.
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