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聚糖类血静粉对经内切除术后出血的患者中血的疗效:随机对照试验
Hengcun Li1, Jiaxuan Zuo, Wenhai Wang
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, State Key Laboratory of Digestive Health, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China .
聚糖血静粉 (PHP) 在100%的非脉动性内切除术后出血的患者中实现了即时的血静,证明不低于内镜剪贴. 这种新的静血粉提供了一种有效和易于使用的替代方案来控制出血.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术 进行内镜手术
- 血液静止 血液静止 血液静止
背景情况:
- 内镜后缩切除术 (EST) 出血带来了挑战,特别是在侧面观看的十二指镜镜中.
- 多糖血静性粉末 (PHP) 在胃肠道出血管理方面表现有前途.
- 对于EST后出血,建立了内镜剪贴,需要进行比较疗效研究.
研究的目的:
- 评估多糖血静粉 (PHP) 对非脉动性EST后出血的疗效.
- 为了确定与内镜剪贴相比,PHP在治疗这种疾病方面的非劣势.
- 评估二次结果,包括延迟出血和整体治疗成功.
主要方法:
- 随机对照试验比较PHP和内镜剪辑在非脉冲性后EST出血的患者.
- 主要终点:即时静血率.
- 二级终点:延迟出血,整体成功率,静血时间和并发症.
主要成果:
- 使用PHP的100%立即静血,而使用内镜剪贴的92.3% (P=0.022).
- 使用PHP观察到更短的静血时间 (50.77s vs 62.81s,P=0.011).
- 对PHP的整体治疗成功率更高 (100%对90.4%,P=0.022),但对不良事件没有显著差异.
结论:
- 聚糖化血静粉末 (PHP) 在非脉动性EST后出血中不劣于内镜剪贴,用于立即的血静.
- PHP为管理这种类型的出血提供了一种有效和用户友好的替代方案.
- 需要进一步的研究来评估PHP在预防延迟出血方面的有效性.
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