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Updated: May 15, 2025

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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对蛋白质抑制剂USP7复合体中能量特征和分子间相互作用的计算分析

M Ziemniak1, U Budniak1, P M Dominiak1

  • 1Biological and Chemical Research Center, Faculty of Chemistry, University of Warsaw, Warsaw, Poland. mziemniak@chem.uw.edu.pl.

Organic & biomolecular chemistry
|April 7, 2025
PubMed
概括

这项研究揭示了静电相互作用是泛素特异性蛋白酶7 (USP7) 抑制剂结合的关键. 计算方法确定了关键残留物和电荷分布,以设计有效的USP7向癌症疗法.

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