针对耐火性勃起功能障碍的阿维普塔迪尔和芬托胺的鼻腔内注射
Abdullah Al-Mitwalli1,2, Fiona Holden1, Angelo Di Giovanni1
1University College London Hospital, Urology, London W1G 8PH, United Kingdom.
艾维普塔迪尔与芬托胺甲基酸盐 (AvP) 内腔鼻内注射 (ICI) 有效地治疗其他治疗失败的男性勃起功能障碍 (ED). 这项研究表明,AVP是耐火性ED的可行的二线选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 药理学 药理学是指药理学的学科.
背景情况:
- 内注射 (ICI) 与阿尔普拉斯塔迪尔是一种常见的治疗勃起功能障碍 (ED) 在不响应代酶5抑制剂 (PDE5i) 的患者.
- 阿尔普拉斯塔迪尔ICI可以引起诸如疼痛 (12%) 和priapism (1%) 等不良反应.
研究的目的:
- 在当代实践中评估阿维普塔迪尔与芬托胺甲基酸盐 (AvP) ICI的疗效.
- 评估AVP作为患有疼痛或失败的患者的替代方案.
主要方法:
- 对308名患有ED的男性进行了回顾性单中心分析.
- 由于无法忍受的疼痛或最大剂量阿尔普拉斯塔迪尔失效而接受AVP ICI的患者.
- 有效性被定义为3个月后恢复透性性活动.
主要成果:
- 总体而言,59%的患者发现AVP ICI有效.
- 与那些未能达到最大剂量 (36%) 的患者相比,阿尔普拉斯塔迪尔的疼痛患者 (76%) 的疗效更高.
- 面部发红发生在22.5%的患者中,缺血性priapism发生在0.3%的患者中.
结论:
- AvP ICI是男性耐火性ED的有效和受欢迎的二线治疗方法.
- 对于那些对其他ED治疗没有反应或经历了不良反应的患者来说,AvP提供了一个可行的选择.
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