低生育人口中维生素D缺乏以及COVID-19封锁的影响
Catherine M Windrim1, Daniel Kane1,2, Grainne Kelleher3
1Obstetrics and Gynecology, Rotunda Hospital, Dublin, Ireland.
概括
接受生育治疗的近40%的妇女的维生素D水平低于最佳水平,季节性和社会经济差异很大. 这一群人中,COVID-19封锁没有影响整体维生素D状况.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏在生殖健康方面越来越令人担忧.
- 了解其在不肥沃人群中的患病率对于有针对性的干预至关重要.
- 社会经济因素可能会影响维生素D的状态.
研究的目的:
- 为了确定维生素D缺乏/不足在女性生育不良患者的患病率.
- 评估维生素D水平的趋势,包括COVID-19封锁的影响.
- 调查维生素D状况的社会经济差异.
主要方法:
- 从2010年3月到2022年5月,对765名女性患者 (平均年龄35.7岁) 进行了回顾性队列研究.
- 维生素D水平分类为缺乏 (<30nmol/L),不足 (30-50nmol/L) 或正常 (>50nmol/L).
- 对COVID前后时期和医疗保健资金状况的比较分析.
主要成果:
- 39.9%的患者的维生素D水平低于最佳水平 (8.8%缺乏,31.1%不足).
- 在COVID前期和后期之间没有观察到维生素D状态的显著差异.
- 与自我资助患者 (35.9%) 相比,国家资助的患者的维生素D水平明显较高 (50.2%).
- 观察到明显的季节性变化,冬季水平较低.
结论:
- 在不孕期妇女中,低于最佳维生素D的高患病率.
- 存在显著的季节性和社会经济差异.
- 常规的维生素D查和有针对性的补充建议不育患者,特别是在冬季和经济弱势群体.
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