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质纤维酸蛋白:小纤维神经病变的潜在生物标志物?

Claus Vinter Bødker Hviid1,2, Nicklas Højgaard-Hessellund Rasmussen3,4, Johan Røikjer3,4,5

  • 1Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. Claus.hviid@rn.dk.

Acta diabetologica
|April 7, 2025
PubMed
概括

血清状纤维酸蛋白 (GFAP) 水平在糖尿病多神经病 (DPN) 患者中较低. 降低GFAP可能表明糖尿病患者的小神经纤维损伤.

关键词:
生物标志物 生物标志物糖尿病 糖尿病 糖尿病糖尿病多神经病变 糖尿病多神经病变格利亚纤维酸性蛋白质是一种纤维酸性蛋白质.定量性感官测试是一种定量性的感官测试.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...