帕金森病相关模式在孤立的REM睡眠行为障碍作为前兆性进展标记:在三个时间点评估的8年随访变化
Giulia Carli1,2, Anna Dortmond3,4, Annette Janzen5
1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. gcarli@med.umich.edu.
概括
用18F-FDG PET评估的帕金森病相关模式 (PDRP) 在孤立的REM睡眠行为障碍 (iRBD) 患者中随着时间的推移增加了表达. 这种生物标志物可以帮助预测转化为帕金森病.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 代谢性脑成像 代谢性脑成像
背景情况:
- 孤立REM睡眠行为障碍 (iRBD) 是包括帕金森病 (PD) 在内的α-synucleinopathies的早期阶段.
- 预测生物标志物对于监测iRBD进展至关重要,需要长期的神经成像研究.
- 来自18F-FDG PET的帕金森病相关模式 (PDRP) 是已知的PD生物标志物,但其在预发性PD跟踪中的实用性尚未确立.
研究的目的:
- 用18F-FDG PET在iRBD患者身上评估8年来PDRP表达的纵向变化.
- 确定PDRP是否可以区分iRBD患者转换为PD和那些没有转换的患者.
主要方法:
- 13名iRBD受试者在基线,4岁和8岁时接受了18F-FDG PET扫描.
- 使用双向重复测量ANOVA分析了PDRP的z分数和运动分数 (UPDRS-III).
- 根据临床诊断,被试被分为转化者 (n=5) 和非转化者 (n=8).
主要成果:
- 对于PDRP z-score (p=0.020) 观察到一个显著的群体*时间相互作用,转换器与非转换器相比,随着时间的推移显示出更明显的增加.
- 转换器在4年和8年随访期间表现出明显更高的PDRPz-score (分别为p=0.042和p=0.024).
- 对于UPDRS-III电机分数也发现了类似的显著影响,表明转换器的电机逐渐受损.
结论:
- 对PDRP进行重复的18F-FDG PET评估对于监测iRBD疾病进展是有价值的.
- 随着时间的推移,PDRP的变化可能成为转化为PD等同核蛋白病变的预测生物标志物.
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