在对结直肠癌进行微创性结直肠手术后,使用炎症参数来确保安全和早期出院
B D N Dos Santos1, C Beruti2, J Azevedo1,3
1Digestive Unit, Champalimaud Foundation, Av Brasilia, 1400-038, Lisbon, Portugal.
Techniques in coloproctology
|April 7, 2025
概括
常规的炎症标志物,如中性粒细胞-淋巴细胞比率 (NLR),可以预测经过微创性结直肠癌手术后的早期术后并发症. 在术后第3天高的NLR表明风险较低,有助于安全的早期出院决定.
科学领域:
- 结肠直肠外科手术是什么意思
- 手术瘤学手术瘤学
- 炎症标志物是一种炎症标志物.
背景情况:
- 微创手术是结直肠癌的标准.
- 40%的患者面临手术后并发症.
- 早期发现并发症至关重要.
研究的目的:
- 评估常规的术后炎症标志物,以预测早期并发症.
- 评估C反应蛋白,格拉斯哥预后得分和中性粒细胞-淋巴细胞比率 (NLR).
主要方法:
- 对397名接受选择性微创性结直肠癌手术的患者进行了回顾性分析.
- 对C反应蛋白,格拉斯哥预后得分和NLR的分析.
- 用Youden指数对截止值进行ROC曲线分析.
主要成果:
- 29.2%的患者有并发症;11.3%有重大并发症.
- 在POD3中,C反应蛋白<125 mg/L,格拉斯哥预测得分<2.12,NLR<5.26预测的并发症风险较低 (p<0.0001).
- 在POD3上NLR<5.26显示了最高的NPV (83%),用于识别不太可能出现并发症的患者.
结论:
- 中性粒细胞-淋巴细胞比率,C-反应蛋白和POD3上的格拉斯哥预后评分预测了微创性结直肠癌手术中的并发症.
- 这些标记物具有高的NPV,识别出具有低并发症风险的患者.
- 炎症标志物为安全的早泄提供了有价值的数据.
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