心血管生物假体的mycobacterium chelonae感染与最近爆发的疫情有关
Johanna Kessel1,2, Axel Braner3, Margo Diricks4,5,6
1Department of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.
Infection
|April 7, 2025
概括
切洛纳菌 (Mycobacterium chelonae) 可以在生物心脏门假肢中引起罕见但严重的感染,甚至在手术后数年. 使用先进的分子和成像技术进行早期诊断对于有效治疗这些假肢移植感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 心血管外科心血管外科
- 微生物学 微生物学
背景情况:
- 切洛纳菌 (Mycobacterium chelonae) 是一种快速生长的非结核菌 (NTM).
- 有时,NTM感染与外来物质有关,包括假肢设备.
- 最近的一次爆发涉及与生物心脏门相关的M. chelonae内心炎.
研究的目的:
- 报告一个M. chelonae感染生物心脏门假体的病例.
- 突出诊断挑战和先进技术在NTM假肢感染中的重要性.
- 强调NTM外体感染的延迟表现的可能性.
主要方法:
- 一个疑似假体膜感染的患者的案例介绍.
- 使用光在现场杂交 (FISH),DAPI,Kinyoun和Ziehl-Neelsen染色.
- 采用了分子方法来识别菌根菌.
- 先进的成像 (PET-CT) 引导诊断和手术干预.
主要成果:
- 证实了M. chelonae感染在被扩展的生物心脏门和相邻的肌肉组织中.
- 分子鉴定将病原体与M. chelonae/综合体联系起来,与已知的疫情有关.
- 患者开始接受抗菌素治疗,并且在临床上保持稳定.
- 在整个诊断过程中,所有菌根菌种都呈阴性.
结论:
- 非结核性菌根细菌是罕见的,在生物假体感染中潜在的未被确诊的病原体.
- 菌根菌外体感染可能在植入后的许多年出现.
- 由于检测难度,分子识别方法对于诊断NTM至关重要.
- 先进的成像和分子/显微技术对于诊断长期的假肢移植感染至关重要.
关键词:
这是一种Mycobacterium chelonae.生物整合 生物整合生物假体轴承管道的管道心脏外科手术是一项心脏手术.内心内膜炎是一种内心内膜炎.菌根细菌感染的感染.在NTM中,NTM是NTM.非结核性菌根杆菌是没有结核的.更多相关视频
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