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美国10个州的侵袭性A型链球菌感染
Christopher J Gregory1, Jennifer Onukwube Okaro1, Arthur Reingold2,3
1Division of Bacterial Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA
|April 7, 2025
概括
从2013年到2022年,美国10个州的侵袭性A型链球菌 (GAS) 感染显著增加. 必须加快公共卫生工作,
科学领域:
- 传染性疾病
- 流行病学
- 公共卫生监测
背景情况:
- 侵袭性A型链球菌 (GAS) 感染对公众健康构成重大威胁,导致严重的发病率,死亡率和经济负担.
- 对于有效的公共卫生干预来说,了解目前的侵入性GAS疾病趋势至关重要.
研究的目的:
- 更新美国10个州的侵袭性GAS疾病发病率.
- 分析2013年至2022年的趋势,确定人口和风险因素的关联.
主要方法:
- 分析了来自活体细菌核监测网络 (349万人) 的基于人口的监测数据.
- 通过从无菌部位或特定临床综合征中隔离GAS来定义病例 (2013-2022年).
- 从2015年开始,全基因组测序用于分离特征和抗菌敏感性测试.
主要成果:
- 侵袭性GAS发病率大幅增加,从每10万人中的3.6人增加到8.2人 (2013-2022年).
- 患病率最高的是65岁以上的人群,相对增长最大的是18至64岁的成年人群.
- 美国印第安人/阿拉斯加原住民,无家可归者,注射毒品者和长期护理机构居民的发病率较高. 抗菌剂对宏类和克林达米辛的耐药性显著增加.
结论:
- 在2013年至2022年期间,美国的侵袭性GAS感染明显增加.
- 迫切需要针对性预防和控制策略,重点关注受到侵袭性气体影响的人口.
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