双胞胎和单身胎儿的胎儿身体组成
Jessica L Gleason1, Wesley Lee2, Zhen Chen3
1Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
JAMA pediatrics
|April 7, 2025
概括
双胞胎胎与单胞胎相比,脂肪组织积累减少,这表明早期的进化适应过程. 胎儿生长的这种差异从怀孕15周开始就显而易见.
科学领域:
- 胎儿的发育 胎儿的发育
- 比较解剖学的比较解剖学
- 进化医学是一种进化医学.
背景情况:
- 在双胞胎怀孕中,第三个月的胎儿生长减速越来越多地被视为一种进化适应.
- 了解双胞胎和单胞胎之间的不同生长轨迹需要评估软组织发育.
研究的目的:
- 为了比较整个怀孕期间双胞胎与单独胎儿的瘦肉和脂肪组织的纵向生长.
主要方法:
- 一项前性队列研究,涉及双双胞胎和单身双胞胎.
- 连续的超声波扫描被用于跟踪胎儿生长和测量胎儿体积以进行组织分析.
- 2009-2019年间,从12个美国临床中心收集了数据,并从2023-2024年进行了分析.
主要成果:
- 双胞胎胎的腹部尺寸和皮下组织厚度明显较小,而单双胎的妊娠期为25至37周.
- 从怀孕15周开始,双胞胎的腿部部分体积 (总体,脂肪和瘦) 始终较小.
- 双胞胎在整个妊娠期间表现出相对较低的脂肪百分比,与单胞胎相比减少了2.7%至4.2%.
结论:
- 双胞胎胎在子宫中积累的脂肪组织比单胞胎要少,早在妊娠15周就开始.
- 这些发现支持了早期进化适应过程影响胎儿生长的假设,这在不复杂的双胞胎怀孕中也是如此.
- 持续观察到双胞胎体型的缩小和脂肪积累的减少,强调了对子宫内条件的适应机制.
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