类固醇的反应预测了Cronkhite-Canada综合征的长期临床和内镜预后
Qiushi Xu1, Chengzhu Ou1, Yunfei Zhi1
1Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, 100730, China.
QJM : monthly journal of the Association of Physicians
|April 7, 2025
概括
克朗希特-加拿大综合征 (CCS) 患者通常在接受类固醇治疗后会有良好的结果. 低剂量类固醇维护疗法可以帮助预防CCS患者的疾病复发.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 临床医学 临床医学
背景情况:
- 克朗希特-加拿大综合征 (CCS) 是一种罕见的胃肠道疾病,具有哈马多,外皮异常和癌症风险增加.
- 类固醇治疗改善了CCS的长期预后,但患者的反应有所不同,需要进一步研究最佳管理.
- 这项研究更新了关于长期CCS预后的知识,并评估了低剂量的类固醇作为维持疗法.
研究的目的:
- 更新对克朗希特-加拿大综合征 (CCS) 患者长期预后的理解.
- 探索CCS中低剂量类固醇维护疗法的疗效和安全性.
- 确定影响CCS患者临床结果的因素.
主要方法:
- 在1999年至2023年期间住院的64名CCS患者的回顾性分析.
- 通过电话采访和门诊访问收集数据,包括临床和内镜发现.
- 考克斯回归模型用于确定临床结果的预测因素.
主要成果:
- 长期随访 (中位数为49.5个月) 显示了有利的整体存活率 (3年后为90.2%).
- 在5年后,类固醇治疗后无复发的存活率为54.4%;较差的类固醇反应与较差的存活率相关.
- 低剂量维护类固醇 (≤10毫克/天普得尼松≥1年) 与以前复发的患者的复发风险降低有关.
结论:
- 对于Cronkhite-Canada综合征的长期结果通常是有利的,特别是在对类固醇反应良好的患者中.
- 低剂量类固醇维持疗法在预防CCS患者的疾病复发方面显示出有前途.
关键词:
克朗希特-加拿大综合征预后 预后 预后这是一个复发的复发.类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型:幸存率 幸存率 生存率更多相关视频
05:57ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
Published on: February 10, 2017
8.4K
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
185
相关概念视频
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
91
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
91
01:29Chronic Pancreatitis II: Collaborative Care
50
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
50
01:17Chronic Bowel Disorders: Introduction
336
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
336
01:26COPD: Management Using Bronchodilators and Corticosteroids
144
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
144
01:30Inflammatory Bowel Disease II: Crohn's Disease
132
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
132
01:20COPD: Pathogenesis and Clinical Features
200
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
200