一个罕见的卡斯特曼病病例,在两个肺部呈现出分散的磨砂玻璃结节:病例报告
Xiaotong Guo1, Caixia Zhu2, Fen Zhang1
1Department of Respiratory and Critical Care Medicine, The General Hospital of Ningxia Medical University, Yinchuan, China.
Medicine
|April 7, 2025
概括
呈现肺结节的多中心卡斯特曼病 (MCD) 是罕见的. 系统化疗改善了症状和成像,强调了病理诊断对有效治疗的重要性.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 卡斯特曼病 (CD) 是一种罕见的淋巴增殖性疾病,原因不明.
- 它呈现为单中心 (单个淋巴结) 或多中心 (多个淋巴结) 的形式.
- 胸部CT对于诊断CD至关重要,通常显示肺部质量和扩大的中枢淋巴结,但多个碎玻璃结节是不常见的.
研究的目的:
- 报告一个罕见的多中心卡斯特曼病病例,呈现双边肺部地面玻璃结节.
- 为了强调这种罕见的CD的诊断挑战和治疗方法.
主要方法:
- 一名48岁的女性患有呼吸道症状,接受了胸部CT检查,发现了多个碎玻璃结节.
- 通过淋巴结活检证实了多中心卡斯特曼病的诊断.
- 最初使用普得尼松的治疗显示出有限的改善,导致开始全身化疗.
主要成果:
- 患者接受了6轮化疗 (cyclophosphamide,vincristine,prednisone),导致胸部CT发现和临床症状显著改善.
- 开始使用低剂量普雷尼松和环胺的长期维持疗法.
结论:
- 卡斯特曼病呈现出多个肺部地面玻璃结节是罕见的,可以被错误诊断.
- 准确的病理检查对于确定诊断至关重要.
- 确定正确的临床和组织病原性亚型对于成功治疗和良好的结果至关重要.
相关概念视频
COPD: Pathogenesis and Clinical Features
2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K
Other Pulmonary Disorders
1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K
Pulmonary Tuberculosis II
2.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.5K
Pulmonary Tuberculosis III
1.8K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.8K
Atypical Pneumonia
88
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
77
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
77


