在患有初级渐进性失言变异的患者中,相关的言语变化和进展
Elisa Canu1,2, Federica Agosta1,2,3, Laura Lumaca1
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology
|April 7, 2025
概括
通过结合语音特征和灰质体积 (GMVs) 来改善初级渐进性失言症 (PPA) 变体的准确诊断. 这种方法增强了PPA亚型的差异化,并揭示了随着时间的推移不同的语音演变模式.
科学领域:
- 神经学 神经学
- 语音语言病理学 语音语言病理学
- 神经成像是一种神经成像.
背景情况:
- 诊断原发性渐进性失言症 (PPA) 变体具有挑战性,影响患者管理.
- 准确地描述PPA亚型对于改善治疗结果至关重要.
研究的目的:
- 为了识别单独或与语言评估和灰质体积 (GMV) 结合的语音特征,这些特征最能区分PPA变体.
- 分析不同PPA变体的连接语音随着时间的推移而发生的演变.
主要方法:
- 一项前性研究,包括95名PPA患者进行神经心理评估",野餐场景"语音测试和脑部MRI.
- 序列特征选择模型结合了语音参数,语言测试和GMV来区分PPA组.
- 线性混合效应模型分析了每种PPA变体内随时间的演讲变化.
主要成果:
- 结合语音参数和GMV的模型显著提高了区分非流利变体PPA (nfvPPA) 和逻辑变体PPA (lvPPA) 的准确性,而不是单独使用标准语言得分.
- 语义变体PPA (svPPA) 通过所有模型准确地与其他PPA组区分开来.
- 观察到不同的语音轨迹:nfvPPA表现出更多的语音错误,svPPA表现出语义/形态语法错误,lvPPA减少了语音速率和句子长度.
结论:
- 结合"野餐场景"语音测试措施和GMV,提高了区分PPA变体的准确性,特别是nfvPPA和lvPPA.
- 语音特征和GMV是了解PPA进展和预测患者结果的宝贵工具.
- 在PPA变体中明显的语音演变模式可以告知有针对性的语音治疗干预.
更多相关视频
13:12Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
44.8K
10:15Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
17.6K
相关概念视频
01:10Higher Mental Functions of the Brain: Language
657
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
657
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
43
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
43
01:27Language and Cognition
301
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
301
01:15Parkinson's Disease: Overview
360
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
360
01:28Lateralization
281
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
281
01:22Language Development
290
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
290