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Updated: May 17, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
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对抗原免疫原性进行评估,该抗原是由转移到抗原呈现细胞的小基因中制成的

María A Villota-Alava1, María A Alfaro-Marenco1, Carlos A Clavijo-Ramírez2

  • 1Department of Microbiology, Universidad Nacional de Colombia, School of Medicine, Immunology and Translational Medicine Research Group, Bogotá, Colombia.

PloS one
|April 7, 2025
PubMed
概括

这项研究表明,呈现瘤表位的工程细胞可以激活T细胞用于癌症免疫治疗. 令人惊的是,共刺激分子对于这种T细胞激活并不必要,简化了疫苗的设计.

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相关概念视频

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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