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对器官选择性纳米颗粒的设计考虑因素

Min-Jun Baek1, Won Hur1, Satoshi Kashiwagi1

  • 1Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.

ACS nano
|April 7, 2025
PubMed
概括

纳米粒子 (NP) 的物理化学特性极大地影响了它们的生物分布和可用于医疗应用的向性. 优化这些特性是克服纳米医学的挑战和实现更强的器官选择性以改善诊断和药物输送的关键.

关键词:
人工智能的人工智能是人工智能.生物分布 生物分布临床应用 临床应用排泄 排泄 排泄高通量选的高通量选机器学习是机器学习.纳米颗粒 纳米颗粒物理化学特性 物理化学特性

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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