侧向下丘脑控制食欲和消费性食之间的过渡吗?
Mette Kongstorp1, Mahesh M Karnani2, James E McCutcheon1
1Department of Psychology, UiT The Arctic University of Norway, Huginbakken 32, 9037, Tromsø, Norway.
Neuropharmacology
|April 7, 2025
概括
侧向下丘脑 (LH) 调节食欲和消费阶段之间的食过渡. 它的开关板式电路架构和多样化的神经元子群控制这些关键的养行为.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 生理学 生理学 生理学
背景情况:
- 食是一种复杂的循环行为,有不同的食欲,消费和终止阶段.
- 了解这些养阶段之间的过渡的神经控制对于推进对养行为知识至关重要.
研究的目的:
- 审查关于横向下丘脑 (LH) 作为食行为中食欲-消费性过渡的调节器的证据.
- 探索LH内不同神经元亚群在控制养阶段和行为转变中的作用.
主要方法:
- 关于横向下丘脑和养行为现有研究的文献综述.
- 对LH神经元子群的分子标记和功能多样性的分析.
- 关于LH在调节养期间行为转变中的作用的综合证据.
主要成果:
- 建议侧向下丘脑 (LH) 作为一个开关板,调节从食欲到消费性食的过渡.
- 在LH中存在不同的神经元亚群,对食欲和消费行为有不同的贡献.
- 有证据表明,这些亚种群可能具有不同的功能身份,影响养控制.
结论:
- 侧向下丘脑 (LH) 在编排养行为转变方面发挥着关键作用.
- 它复杂的电路架构,涉及多样化的神经元子群,是调节养阶段之间的转变的关键.
- 需要进一步的研究,以充分阐明LH亚群的功能性身份及其在控制养行为的精确作用.
相关概念视频
Regulation of Food Intake
155
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
155
Primary Motives: Hunger and Thirst
118
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
118
Diencephalon: Hypothalamus and Coordination
1.2K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
1.2K
Diencephalon: Anatomical Regions
1.4K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses...
1.4K
Neural Regulation
39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K
Hormonal Regulation
43.0K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.0K


