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Updated: May 15, 2025

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使用MRI衍生的放射学预测质瘤中的1p/19q代分离状态;对诊断准确性的系统性审查和元分析

Amir Mahmoud Ahmadzadeh¹, Nima Broomand Lomer¹, Mohammad Amin Ashoobi¹

¹From the Department of Radiology (A.M.A., M.A., F.S.T.) and Student Research Committee (D.E., B.G, M.V., S.A.J.), Mashhad University of Medical Sciences, Mashhad, Iran; Department of Radiology (N.B.L), University of Pennsylvania, Philadelphia, Pennsylvania, United States; Trauma Research Institute (M.A.A), Guilan University of Medical Sciences, Rasht, Iran; Department of Radiology (G.B., S.F.), Mayo Clinic, Rochester, Minnesota, United States.

AJNR. American journal of neuroradiology

|April 7, 2025

概括

磁共振成像 (MRI) 衍生的放射学在预测质瘤1p/19q代选择状态方面显示出有前途的非侵入性. 这些模型为改善质瘤特征和治疗决策提供了潜力.

科学领域:

神经瘤学神经瘤学
医学成像医学成像
遗传学是一个遗传学.

背景情况:

1p/19q编是质瘤中关键的遗传标记物,影响预后和治疗.
目前的检测方法包括侵入性组织活检.

研究的目的:

系统地审查和元分析MRI衍生放射学模型的性能,以预测质瘤1p/19q共选状态.

主要方法:

在PubMed,Web of Science,Embase和Scopus进行了全面的文献搜索.
选择了评估放射学模型对1p/19q代选择预测的研究.
使用方法论放射学评分 (METRICS) 评估了研究质量;诊断性能被聚合并评估异质性.

主要成果:

包括28项研究;10项进行了元分析.
该元分析报告了0.82的聚合灵敏度,0.80的特异性,以及0.87.87的曲线下面积 (AUC).
小组分析表明基于国家和细分方法的变化.

结论:

来自MRI的放射学模型对质瘤1p/19q代选择具有很强的预测性能.
这些非侵入性模型显示了质瘤表征和指导治疗决策的潜力.

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