在第二个三个月使用MRI成像测量脑下结节空间
Onur Simsek1, Amirreza Manteghinejad1, Mix Wannasarnmetha1
1From the Division of Neuroradiology, Department of Radiology (O.S., A.M., M.W., A.K., S.R.T., D.Z., E.S.S, M.T.W.) Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine (S.R.T., D.Z., E.S.S., M.T.W), Philadelphia, PA, USA.
AJNR. American journal of neuroradiology
|April 7, 2025
概括
这项研究建立了胎儿正常下关节空间 (SAS) 深度参考范围,用于第二个三个月. 这些测量对于使用胎儿大脑MRI诊断早期中枢神经系统 (CNS) 疾病至关重要.
科学领域:
- 神经成像是一种神经成像.
- 胎儿的发育 胎儿的发育
- 定量解剖学 定量解剖学
背景情况:
- 脑下空间 (SAS) 是发育中的胎儿内区的关键组成部分.
- 胎儿大脑MRI越来越多地用于早期诊断中枢神经系统 (CNS) 疾病.
- 为正常的SAS深度建立基于年龄的标准对于准确解释胎儿神经成像至关重要.
研究的目的:
- 在健康胎儿中为 supratentorial 副arachnoid 空间提供 2D 参考测量.
- 建立妊娠第19周和第27周之间的子arachnoid空间深度的规范性数据.
- 支持胎儿大脑MRI的临床和研究应用.
主要方法:
- 对159个胎儿大脑MRI (19-27周怀孕) 的横截面研究,没有明显的病理.
- 双边测量前部,岛屿和下部部SAS宽度.
- 使用位置,尺度和形状 (GAMLSS) 的通用添加模型创建百分点曲线.
主要成果:
- 评价者之间的可靠性 (ICC) 从0.667到0.943.3不等.
- 在考虑年龄后,没有观察到左侧和右侧或性别之间的SAS测量的显著差异.
- 为每个SAS测量生成了一个单一的参考图表.
结论:
- 胎儿下关节的空间深度表明,在第二个三个月内适应不断增长的胎儿.
- 这项研究为 supratentorial subarachnoid空间提供了基本的规范性参考范围.
- 这些数据将有助于对胎儿大脑发育和病理学的临床评估和研究.
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