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吸烟,酒精和萨尔科佩尼亚风险:孟德尔的随机化研究
Tingting Sha1,2,3, Yuqing Zhang4,5, Amit D Joshi6
1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
BMJ open
|April 7, 2025
概括
吸烟因果性地增加了肉症的风险,影响了肌肉质量和力量. 然而,在这项遗传研究中,酒精消费没有显示出与肉症有显著的因果关系.
科学领域:
- 遗传学和流行病学
- 肌肉骨健康 肌肉骨健康
- 药物使用研究研究 药物使用研究
背景情况:
- 观察性研究表明,吸烟会增加肉症的风险,而酒精可能会减少这种风险.
- 在以前的研究中,潜在的混和反向因果关系需要因果推断方法.
- 标志着肌肉损失的萨尔科佩尼亚是一个日益严重的公共卫生问题.
研究的目的:
- 为了调查吸烟和饮酒与肉症风险之间的因果关系.
- 利用门德尔的随机化来克服观察性研究的局限性.
- 评估这些物质对肌肉力量和肌肉量的影响.
主要方法:
- 使用遗传变异的门德尔随机化研究设计.
- 数据来源于英国生物银行,包括电子健康记录.
- 分析基因决定的吸烟 (香烟/天) 和酒精 (饮料/周) 对皮症,握力和尾肌肉质量的分析.
主要成果:
- 增加的基因决定的吸烟与更高的肉症风险相关 (OR=2.51).
- 吸烟与握力降低 (β=-0.63公斤) 和尾肌肉质量降低 (β=-0.22公斤) 相关.
- 酒精消费没有与肉症或瘦身质量产生因果关系,尽管与握力下降有关.
结论:
- 基因决定的吸烟因果关系与沙科佩尼亚风险增加有关.
- 酒精消费似乎对皮症风险没有因果关系.
- 研究结果支持针对戒烟的有针对性的干预措施,以减轻肉症的风险.
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