揭示肥胖相关基因与多发性硬化症之间的因果关系:一个系统的文献综述
Ali Jafari1,2, Sara Khoshdooz3, Melika Arab Bafrani4
1Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Brain and behavior
|April 8, 2025
概括
与肥胖相关的基因如FTO,FAIM2,NPC1,GNPDA2,MC4R和BDNF可能会影响多发性硬化症 (MS) 的风险和进展. 本综述探讨了它们在多发性硬化病原和易感性中的复杂作用.
科学领域:
- 遗传学 是一个遗传学.
- 神经免疫学 神经免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 多发性硬化症 (MS) 是一种复杂的神经退行性疾病,受遗传和生活方式因素的影响.
- 研究与肥胖相关的基因为MS病因学提供了潜在的见解.
- 六个关键基因 (FTO,FAIM2,NPC1,GNPDA2,MC4R,BDNF) 已被检查出它们在MS中的作用.
研究的目的:
- 系统地审查关于六种与肥胖相关的基因与多发性硬化症之间的关联的文献.
- 阐明这些基因对MS易感性和疾病进展的潜在影响.
主要方法:
- 在主要的科学数据库 (Embase,Scopus,Cochrane,Web of Science,PubMed) 进行了全面的系统文献搜索,截至2024年7月.
- 关键词包括特定的基因名称和"多发性硬化症",以确定相关研究.
- 从最初的2108篇论文中,选出了27篇相关论文进行深入审查.
主要成果:
- 脂肪质量和肥胖相关 (FTO) 基因可能通过代谢和炎症途径影响MS易感性.
- FAS细胞亡抑制分子2 (FAIM2) 和尼曼-皮克病类型C1-like1 (NPC1) 可能在MS病变发生过程中发挥作用,需要进一步研究.
- 黑色皮质-4受体 (MC4R) 具有与MS相关的神经保护和抗炎作用,而脑衍生神经营养因子 (BDNF) 在神经元存活率和MS风险中起着复杂的作用.
结论:
- 与肥胖相关的基因与多发性硬化症风险和疾病过程有显著的关联.
- 这些发现为MS的遗传基础提供了新的见解.
- 需要进一步的研究,以充分阐明这些基因影响多发性硬化症的确切机制.
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