骨关节炎的人类阴道液改变了CoCrMo电化学特性,根据患者的具体情况
Bailey Bond1, Madison N Brown1, Michael A Kurtz2
1Department of Orthopaedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center-Campbell Clinic, Memphis, Tennessee, USA.
概括
在全膝关节整形术 (TKA) 中,--- (CoCrMo) 的电化学行为因个体患者的突液而异. 这种特定于患者的腐蚀会影响植入物性能和生物反应.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 电化学 电化学 电化学
背景情况:
- ---合金 (CoCrMo) 是全膝关节整形术 (TKA) 的标准.
- 有关与CoCrMo磨损碎片相关的局部不良组织反应存在担忧.
- CoCrMo和突液之间的电化学相互作用尚未完全理解.
研究的目的:
- 为了研究 CoCrMo 在 TKA 患者的人类突液中的电化学行为.
- 为了比较CoCrMo在突液中的电化学特性与酸盐缓冲盐水 (PBS).
- 评估患者特定生理环境对CoCrMo腐蚀的影响.
主要方法:
- 在手术前立即从118名TKA患者收集突液.
- 使用一个三电极的电化学电池与CoCrMo工作电极.
- 进行了开放电路电位 (OCP),电化学阻抗光谱和线性极化测试.
主要成果:
- 在不同患者之间,CoCrMo的电化学特性存在显著差异.
- 突液的结果与PBS的结果差异很大 (p < 0.05).
- 测量OCP的范围从-0.38到0.15V;腐蚀潜力 (Ecorr) 的范围从-0.95到-0.2V.
- 即时腐蚀速率 (1/Rp) 跨越了近四个数量级.
结论:
- 人类突液显著影响CoCrMo合金的电化学行为.
- 患者对患者的变化表明当地的生理环境是关键因素.
- 这些发现对了解包括TKA在内的骨科植入物的长期生物反应有意义.
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