大脑功能连接的年龄差异是工作记忆的主动干扰的基础
P Andersson1, M G S Schrooten2, J Persson1,3
1Center for Life-Span Developmental Research (LEADER), School of Behavioral, Social and Legal Sciences, Örebro University, Sweden.
Human brain mapping
|April 8, 2025
概括
随着年龄的增长,人们解决工作记忆 (WM) 的主动干扰的能力下降,这与大脑连接的变化有关. 这些与WM和静止状态功能连接 (rsFC) 模式的年龄相关差异是显著的.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 衰老研究研究 衰老研究
背景情况:
- 老龄化通常导致工作记忆 (WM) 衰退,影响认知控制.
- 减少解决主动干扰 (PI) 的能力是与年龄相关的WM损伤的关键因素.
- 在成年人一生中,WM中的PI与静止状态功能连接 (rsFC) 之间的关系尚不清楚.
研究的目的:
- 研究工作记忆 (WM) 中的主动干扰 (PI) 与静止状态功能连接 (rsFC) 之间的关联.
- 检查成年人一生中这种关联的横截面和纵向变化.
- 探索与WM控制相关的大脑连接模式的与年龄相关的差异.
主要方法:
- 采用基于种子和数据驱动的方法来分析rsFC.
- 在成年人寿命中,研究了横截面 (n=237) 和纵向 (n=134) 的相关性.
- 利用全脑多变量模式分析来识别年龄差异性连接模式.
主要成果:
- 在WM中的PI与年轻/中年人与老年人的明显的下额 (IFG) rsFC模式有关.
- 老年人表现出更强的IFG-vermis和较弱的IFG-caudate连接性,PI增加.
- 纵向数据显示IFG-insula和IFG-anterior cingulate皮质连接性减少,与老年人PI控制受损相关.
结论:
- 休息状态功能连接 (rsFC) 与控制工作记忆 (WM) 中主动干扰 (PI) 的能力有显著的关联.
- 这些关联是根据年龄调节的,在年轻/中年和老年人中观察到不同的模式.
- 研究结果表明,与年龄相关的大脑连接的变化是WM控制和PI分辨率下降的基础.
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