运动认知风险综合征和心血管疾病风险:基于人口的研究
Charlotte Menart1, Amber Yaqub1, Lisanne Dommershuijsen2
1Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
概括
运动认知风险综合征 (MCRS) 增加了心血管疾病的风险,特别是冠心病. 轻度认知障碍 (MCI) 没有显示这种关联,这表明MCRS具有血管起源.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 研究认知衰退综合征的血管起源.
- 比较运动认知风险综合征 (MCRS) 和轻度认知障碍 (MCI).
研究的目的:
- 确定MCRS和MCI在与发生心血管疾病 (CVD) 的关联方面是否有所不同.
- 探索MCRS和MCI的血管支柱.
主要方法:
- 从鹿特丹研究中对2710名没有痴呆症的个人进行了基于人口的研究.
- 通过认知投诉和缓慢步行定义的MCRS;通过认知投诉和客观认知障碍定义的MCI.
- 考克斯的比例危险模型分析了心血管疾病风险,调整了年龄,性别和心血管风险因素.
主要成果:
- 确定了MCRS (8.2%) 和MCI (5.5%) 的流行率.
- MCRS与心血管疾病风险增加相关 (HR=1.54),而MCI没有 (HR=0.85).
- MCRS与较高的冠状动脉心脏病和中风风险相关;MCI没有显著的关联.
结论:
- 与MCI不同的是,运动认知风险综合征与心血管疾病风险增加有关.
- 这些发现支持MCRS中重要的血管成分,有助于痴呆风险.
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