最小的微血管阻力:连续和玻尿酸热稀释之间的协议
Thabo Mahendiran1,2, Daniëlle Keulards3, Nico H J Pijls3
1Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.
概括
连续热稀释准确地测量了微血管阻力 (Rμ,hyper),与PET成像非常一致. 然而,微循环阻力指数 (IMR) 与心痛患者的侵入性Rμ,hyper没有相关性.
科学领域:
- 心血管研究的心血管研究.
- 医学成像医学成像
- 血液动力学 血液动力学
背景情况:
- 连续热稀释量化绝对微血管阻力 (Rμ,hyper),这是微血管功能的关键指标.
- 增加Rμ,hyper表明微血管功能障碍.
- 玻尿酸热稀释提供了微循环阻力 (IMR) 的指数,作为Rμ,hyper.的替代品.
研究的目的:
- 为了比较侵入性Rμ,超 (连续热稀释) 与黄金标准 [15O]H2O PET Rμ,超.
- 评估侵入性Rμ,hyper和IMR之间的相关性.
主要方法:
- 在24名患者 (46次测量) 中,对PET Rμ,hyper进行了入侵Rμ,hyper的准确性评估.
- 侵入性Rμ,hyper和IMR之间的一致性在250名患有心痛和非阻塞性冠状动脉的患者中进行了评估.
主要成果:
- 侵入性Rμ,超与PETRμ,超有很强的相关性 (r=0.86),绝对一致性很好 (ICC=0.82).
- 在侵入性Rμ,hyper和PET Rμ,hyper之间没有发现显著的系统或比例偏差.
- 侵入性Rμ,hyper与IMR没有显著的相关性 (r=0.11).
结论:
- 来自连续热稀释的侵入性Rμ,hyper显示出与非侵入性PET Rμ,hyper.的优异一致.
- 在患有心痛和非阻塞性冠状动脉的患者中,IMR与侵入性Rμ,hyper没有显著的相关性.
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