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多微量元素补充对生化标志物和手术后结果在接受选择性心脏手术的患者的效果
Mehran Amirizadeh1, Gohar Eslami2, Negar Shafaei-Bajestani3
1Department of Pharmacotherapy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
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概括
在冠状动脉旁路移植 (CABG) 手术后补充微量元素可能会改善患者的治疗结果. 补充和铜等微量元素有助于降低CABG患者的C-反应蛋白水平和潜在的死亡率.
科学领域:
- 心脏病学 心脏病学
- 营养生物化学 营养生物化学
- 外科手术的结果
背景情况:
- 冠状动脉旁路移植 (CABG) 手术是冠状动脉疾病 (CAD) 患者的重要干预措施.
- 基本微量元素的低血清水平与接受CABG的患者的不良结果有关.
- 确定减轻这些风险的干预措施对于改善患者预后至关重要.
研究的目的:
- 评估微量元素补充剂对CABG后术后恢复的影响.
- 评估Addamel©,一种微量元素混合物的作用,对CABG后的关键临床和生化标志物的影响.
主要方法:
- 一项随机临床试验,涉及200名接受内CABG的患者.
- 参与者在手术后3天接受了Addamel© (微量元素) 或同位素盐水.
- 术后测量包括血中,,铜,和铁的度,以及高度敏感的C反应蛋白 (hs-CRP).
主要成果:
- 微量元素补充剂导致血铜和水平在第三天增加.
- 虽然hs-CRP最初在两组中都增加,但在补充组中,它在第二天下降.
- 在Addamel©组中观察到较低的30天死亡率趋势,血和死亡率,以及手术前CRP和SOFA得分之间存在显著的负相关性.
结论:
- 微量元素补充似乎对接受CABG的患者有益.
- 在CABG后使用Addamel©可能有助于维持血清微量元素度并降低血CRP水平.
- 需要进一步的研究来证实对死亡率和其他临床终点的影响.
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