在 rhesus macaques 中的 SIV/SARS-CoV-2 联合感染会影响病毒分泌,宿主免疫力,微生物组和病毒进化
Megan N Fredericks1,2, Zohar Kolodner1,2, Adam Waalkes3
1Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
Research square
|April 8, 2025
概括
中的类似免疫缺陷病毒 (SIV) 感染加剧了SARS-CoV-2的结果,模仿了HIV感染者 (PLWH) 的COVID-19. 这种SIV-SARS-CoV-2联合感染模型显示免疫力受损和病毒演变.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PLWH) 面临更高的严重COVID-19风险.
- 了解HIV/SARS-CoV-2联合感染对于公共卫生至关重要.
研究的目的:
- 为了研究HIV/SARS-CoV-2联合感染的猿类免疫缺陷病毒 (SIV) 模型.
- 评估SIV对SARS-CoV-2病原,免疫力和病毒演变的影响.
主要方法:
- 七只SIV+ rhesus被SARS-CoV-2同时感染.
- 评估了COVID-19的严重程度,病毒复制,抗体和T细胞反应以及微生物社区的变化.
- 在上呼吸道中监测SARS-CoV-2的演变.
主要成果:
- 所有的COVID-19病例均为轻微的.
- 在14天内,SARS-CoV-2在上呼吸道中复制.
- 观察到抗SARS-CoV-2抗体和T细胞生成受损.
- 在呼吸道和肠道中发生过渡性微生物变化.
- 检测到SARS-CoV-2进化的证据.
结论:
- 在中SIV/SARS-CoV-2联合感染在PLWH中模拟了COVID-19的方面.
- SIV 损害了抗SARS-CoV-2 免疫力,可能会增加病毒的分泌和进化.
- 这种模型对于研究HIV/SARS-CoV-2共感染及其影响是有价值的.
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