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Updated: Jun 9, 2026

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.
07:46

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

Published on: December 11, 2020

误解突变物SMARCB1破坏了SWI/SNF复合体的稳定性和重塑活动

Garrett W Cooper1,2, Benjamin P Lee1,2, Won Jun Kim3,4

  • 1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Research square
|April 8, 2025
PubMed
概括

对SMARCB1的深度突变扫描揭示了错误的突变,这些突变损害了瘤抑制功能,挑战了当前的癌症诊断. 这些突变破坏了染色质重塑,类似于完成基因失活.

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ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast07:31

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

Published on: June 30, 2022

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