高影响性疼痛预测主观和客观认知衰退的发生率
Javier Tamargo1, Glenn Smith2, Li Chen
1University of Florida.
Research square
|April 8, 2025
概括
高冲击性慢性疼痛显著增加了老年人认知能力下降和痴呆症的风险. 对疼痛的早期干预可能有助于保持认知功能和预防痴呆症.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性疼痛影响大多数老年人,造成认知障碍和痴呆症的重大风险.
- 高冲击性疼痛,定义为限制日常活动的疼痛,是认知衰老研究中需要考虑的关键因素.
研究的目的:
- 研究50岁及以上成年人高冲击性疼痛与主观认知衰退 (SCD) 之间的关联.
- 确定高冲击性疼痛是否预测客观认知障碍,特别是与APOE4等位基因相关.
主要方法:
- 在健康和退休研究 (2004-2020) 中,分析了13763名50岁以上的成年人的数据.
- 对社会人口统计学和临床因素进行统计调整,以评估疼痛对认知能力下降的独立影响.
- 对疼痛对SCD和客观认知障碍的预测能力的检查,根据APOE4等位基因状态进行分层.
主要成果:
- 高冲击性疼痛与SCD的更高的患病率和发病率有关,而不是没有或低冲击性疼痛.
- 高冲击性疼痛预测客观认知障碍的风险增加,特别是在没有APOE4等位基因的个体中.
- 在非APOE4载体群体中,高冲击性疼痛比单独的SCD更强烈地预测未来的认知障碍.
结论:
- 高冲击性疼痛是老年人认知能力下降和痴呆症的重要,独立的风险因素.
- 针对高冲击性疼痛,甚至从中年开始,可能是减轻认知衰老风险的可行策略.
- 进一步的研究至关重要,以阐明疼痛和认知障碍之间的联系机制,并开发有效的干预措施.
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