肠道微生物群的差异和结直肠癌亲属和健康个体的疾病风险
Huifen Wang1,2, Weiwei Zhu1,2, Jun Lei1,2
1Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in cellular and infection microbiology
|April 8, 2025
概括
研究人员确定了结直肠癌 (CRC) 亲属的肠道微生物群差异,表明CRC风险升高. 一个新的预测模型有助于在高风险个体的早期检测.
科学领域:
- 微生物组研究的研究.
- 癌症基因组学 癌症基因组学
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 风险评估至关重要,特别是在高风险人群中.
- 了解与CRC相关的肠道微生物组变化是一个活跃的研究领域.
- 早期识别易感性和预防策略对于CRC管理至关重要.
研究的目的:
- 在有结直肠癌家族史的个人中调查肠道微生物组合.
- 开发和验证用于评估结直肠癌风险的预测模型.
- 确定与CRC易感性相关的微生物生物标志物和生活方式因素.
主要方法:
- 来自多个队伍的1647个人的便样本的全基因组元基因组测序.
- 开发和验证一种基于随机森林的疾病概率 (POD) 预测模型.
- 对肠道微生物组成的分析,重点关注特定的细菌属及其与CRC风险的关联.
主要成果:
- 在CRC亲属和对照之间观察到肠道微生物组组成的显著差异.
- 在CRC亲属中发现了*Fusobacterium*和*Bacteroides*的丰富,以及*Coprococcus*和*Roseburia*的减少.
- 饮食红肉摄入量被确定为危险因素,POD模型表明未受影响亲属的CRC风险较高.
结论:
- 肠道微生物组分析可以帮助评估结直肠癌风险,特别是在高危人群中.
- 开发的POD模型为识别CRC风险增加的表面健康个体提供了一个新的框架.
- 需要进一步的研究来证实在亲属和共享环境中增加POD的统计学意义.
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