基因风险的轨迹跨越了饮酒行为和饮酒使用的各个维度
Jeanne E Savage1, Fazil Aliev2, Peter B Barr3,4
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
medRxiv : the preprint server for health sciences
|April 8, 2025
概括
饮酒行为的遗传风险得分与更高的饮酒水平有关,但与随着时间的推移饮酒轨迹的联系有限. 然而,对酒精问题的遗传风险预测了饮酒量的增加,这表明对有风险的个体进行个性化干预的时间.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学遗传学 精神病学遗传学
- 发展心理学 发展心理学
背景情况:
- 酒精使用行为 (AUB) 是遗传的,在整个发育过程中,遗传影响会发生变化.
- 之前的研究往往忽略了这些发育动态,当识别与AUBs相关的基因.
研究的目的:
- 调查AUB与AUB的遗传关联如何在整个发展过程中展开.
- 利用多基因分数 (PGS) 的纵向建模来理解这些动态.
- 为了确定干预的关键时期和AUB相关基因背后的机制.
主要方法:
- 使用GWAS数据创建了酒精消费,问题,酒偏好和外部化行为的多基因分数 (PGS).
- 开发了潜在增长曲线模型来分析AUB的轨迹.
- 在六个纵向队列中测试PGS作为潜增长因子 (截面,斜率,二次) 的预测因子.
主要成果:
- 所有AUB的更高的PGS与更高的平均水平的酒精消费和重度插曲性饮酒有着强烈的关联.
- 遗传指数在很大程度上与群体的饮酒轨迹无关.
- 对酒精问题的PGS始终预测,随着时间的推移,酒精消费的轨迹会越来越大.
结论:
- 与AUBs的遗传关联在行为,发育时间和队列中表现出异质性.
- 未来的遗传研究应该考虑这种异质性,以更好地了解AUB病因学.
- 个体遗传特征,特别是对于酒精问题,可以为个性化干预时间表提供信息.
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