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Updated: May 15, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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功能障碍的高密度胆固醇促进血小板亡和血栓形成,在家族性高胆固醇血中

Karthik Dhanabalan, Honglei Li, Patricia G Yancey

    medRxiv : the preprint server for health sciences
    |April 8, 2025
    PubMed
    概括

    在家族性高胆固醇血症 (FH) 中,高密度脂蛋白 (HDL) 变为前血栓,增加血小板功能障碍和血栓形成风险. 一种脂质过氧化清除剂-2-基胺 (2-HOBA) 有效地逆转了这些影响,为FH患者提供了潜在的治疗策略.

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