介导心性类固醇在哺乳动物血细胞中的作用的机制
Yuri M Poluektov1, Olga D Lopina1,2, Maria A Strelkova1
1Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, Russia.
Frontiers in pharmacology
|April 8, 2025
概括
心肌类固醇 (CTSs) 通过与Na,K-ATPase结合,影响血细胞功能. 本综述探讨了CTS如何影响红细胞,白细胞和血小板,揭示了它们在生理调节和疾病中的关键作用.
科学领域:
- 生物化学 生物化学
- 生理学 生理学 生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心脏性类固醇 (CTS) 是一种已知与Na,K-ATPase结合的类固醇化合物.
- 虽然在历史上被用于外源性心力衰竭,但内源性CTS现在在哺乳动物中得到了认可.
- 病理中的内源性CTS水平升高表明在生理调节中起作用,但它们对血液细胞的影响尚不清楚.
研究的目的:
- 审查心肌类固醇 (CTSs) 对动物和人类血细胞的影响.
- 基于已知的哺乳动物细胞反应,分析血液细胞中CTS作用机制.
- 为了突出改变CTS水平对血细胞功能的影响.
主要方法:
- 对心血管类固醇 (CTSs) 对血液细胞的影响的文献综述.
- 对涉及Na,K-ATPase抑制和信号级联激活的CTS机制的分析.
- 对不同类型 (红细胞,白细胞,血小板) 和物种的CTS影响进行比较.
主要成果:
- CTS通过Na,K-ATPase抑制 (高度) 或信号 (低度) 影响血液细胞.
- 所有血细胞类型都表达不同亲和度的Na,K-ATPase异型 (α1和α3),导致不同的反应.
- 内源性CTS增加改变红细胞Na,K-ATPase活动,调节白细胞炎症,并影响血小板激活.
结论:
- 改变心脏类固醇 (CTS) 水平显著影响血细胞功能,有助于适应性反应.
- 由于Na,K-ATPase异型的差异,动物模型可能不适合研究CTS对白细胞的影响.
- 了解CTS对血液细胞的作用对于解释其生理和病理作用至关重要.
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