作为SARS-CoV-2的神经炎症进入因子的Neuropilin-1在接种疫苗的COVID-19患者中减弱:一个病例对照研究
Faezeh Hosseini1,2, Abbas Azadmehr2, Kiarash Saleki1,3,4
1Student Research Committee, Babol University of Medical Sciences Babol Iran.
Health science reports
|April 8, 2025
概括
在COVID-19患者中,Neuropilin-1 (NRP1) 和Interleukin-6 (IL-6) 的基因表达升高,与疾病严重程度相关. 然而,疫苗接种似乎降低了NRP1水平,这表明在SARS-CoV-2感染中发挥了复杂的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 由SARS-CoV-2引起的COVID-19涉及通过像Neuropilin-1 (NRP1) 这样的受体进入宿主细胞.
- 由包括IL-6在内的因素驱动的细胞因子风暴,导致COVID-19的严重表现和死亡率.
研究的目的:
- 在COVID-19患者中调查NRP1和IL-6的基因表达水平.
- 探索这些基因表达和疾病严重程度之间的相关性.
主要方法:
- 从80名COVID-19患者和30名健康对照人群中分离了周围血液单核细胞 (PBMC).
- 实时PCR用于测量NRP1和IL-6基因相对于GAPDH家政基因的表达水平.
主要成果:
- 与对照组相比,COVID-19患者的NRP1基因表达显著高于对照组.
- 在未接种疫苗的COVID-19患者中,IL-6基因表达也显著增加.
- 在IL-6和NRP1表达水平之间观察到正相关性 (p=0.03).
- 有趣的是,与未接种疫苗相比,接种疫苗的人群中NRP1的表达率较低.
结论:
- 在COVID-19患者中,尤其是中度至重度病例中,NRP1和IL-6表达的升高表明它们作为疾病严重程度的潜在生物标志物的作用.
- 这些基因在炎症和免疫病理学中的参与要求进一步调查针对COVID-19和类似疾病的治疗策略.
更多相关视频
07:31Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
Published on: August 23, 2022
05:49Pseudotyped Viruses As a Molecular Tool to Monitor Humoral Immune Responses Against SARS-CoV-2 Via Neutralization Assay
Published on: November 21, 2023
相关概念视频
Conjugated Proteins
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Coronavirus
Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
