在骨科患者群体中,大麻二醇的感知和使用
Bradley Lambert1, Karen L Hernandez1, Haley Goble1
1Department of Orthopedics & Sports Medicine, Houston Methodist Hospital, Houston, Texas.
JB & JS open access
|April 8, 2025
概括
Cannabidiol (CBD) 用于治疗疼痛在骨科中很常见,超过40%的患者使用它. 障碍包括缺乏证据和医生处方的选择,强调需要进一步研究.
科学领域:
- 整形外科手术 整形外科手术
- 疼痛管理 疼痛管理
- 大麻素治疗药物 大麻素治疗药物
背景情况:
- 与其他医疗领域相比,在骨科中对大麻素 (CBD) 用于疼痛管理的研究不足.
- 这项研究调查了骨科患者群体中的CBD意识,使用和感知.
- 假设包括患者对CBD的高度认识和与一般人群相比的使用率.
研究的目的:
- 评估在骨科患者中使用大麻二醇 (CBD) 的患病率.
- 了解患者的看法和使用或不使用CBD治疗疼痛的原因.
- 确定CBD在骨科疼痛治疗中采用CBD的障碍和促进因素.
主要方法:
- 在手术前对500名成年骨科患者进行了一项调查.
- 匿名调查收集了有关人口统计,疼痛水平,CBD知识,使用和态度的数据.
- 使用REDCap平台进行安全和匿名的数据收集.
主要成果:
- 超过80%的患者曾听说过CBD,41.8%报告之前使用过CBD,主要用于疼痛管理.
- 不使用的主要原因包括获得CBD的不确定性和缺乏熟悉性.
- 大多数患者 (超过80%) 认为CBD可以有效治疗疼痛,如果有更多关于安全性和有效性的证据,许多人愿意考虑处方CBD.
结论:
- 很大一部分骨科患者都知道并使用CBD治疗疼痛.
- 对于CBD使用的障碍包括对安全性和有效性的更强有力的证据的需求,以及药品级的医生处方选择的可用性.
- 结果强调了大规模随机试验的必要性,以支持在骨科疼痛管理中使用制药级CBD.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
192
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
192
Analgesia and Pain Management
403
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
403
Drug Delivery: Parenteral Route
337
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
337
Local Anesthetics: Clinical Application as Spinal Anesthesia
559
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
559
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
141
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
141


