相关实验视频

Updated: Aug 8, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

深度大脑刺激对多发性硬化症震和新兴目标的应用:一个迷你回顾

Zengrui Zhang¹, Haiyan Tang¹, Yang Li¹

¹Department of Neurology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, 313000, People's Republic of China.

Therapeutics and clinical risk management

|April 8, 2025

概括

深度大脑刺激 (DBS) 有效地抑制了多发性硬化症 (MS) 的震. 用DBS针对不确定的区域 (Zona Incerta,简称ZI) 显示出对震管理的前景,提供比体刺激更好的结果和更少的副作用.

科学领域:

神经学神经学
神经外科神经外科
生物医学工程生物医学工程

背景情况:

多发性硬化症 (MS) 震是导致残疾的重要原因.
对于MS震的药理疗法通常具有有限的疗效.
深度大脑刺激 (DBS) 已成为一种潜在的治疗选择.

研究的目的:

研究DBS在各种大脑区域的有效性和安全性,以抑制MS震.
为了比较针对不确定的区域 (Zona incerta,ZI) 的DBS与thalamus的影响.
为了阐明由ZI刺激抑制震的基础的神经生物学机制.

主要方法:

对MS震抑制的DBS研究的系统文献综述.
对神经解剖学连接和涉及的神经递质系统 (例如GABAergic剂) 的分析.
在ZI和thalamic目标之间对减轻震和副作用概况的比较评估.

主要成果:

在体和下体区域,特别是ZI的DBS在减少MS震方面表现出有效性.
包括双边方法在内的ZI刺激显示出显著的震控制.
与体DBS相比,ZI DBS似乎提供了更好的副作用概况.

结论:

不确定区域 (ZI) 是一个非常有前途的手术目标,用于改善MS震.
ZI的DBS为MS震管理提供了一个潜在的优越治疗选择.
对ZI DBS的进一步研究可以提高对MS震抑制的理解和应用.

关键词:

深度大脑刺激刺激大脑不同的目标,不同的目标.多发性硬化症多发性硬化症震,震,震动,这是一个很大的问题.

更多相关视频

$MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor$ 05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

相关概念视频

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.