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虫感染有利于肺中性粒细胞的重编程和增殖

Fei Chen^1,2, Suheyla Batirbek^1,2, Vanessa Espinosa^1,3

¹Center for Immunity and Inflammation, The State University of New Jersey, Newark, New Jersey, USA.

bioRxiv : the preprint server for biology

|April 8, 2025

概括

虫感染会诱导一种新的中性粒细胞表型,其特征是细胞死亡减少和增殖增加,与细菌或真菌感染不同. 这一发现揭示了一种长寿的循环中性粒细胞子集,对于对抗寄生虫入侵者至关重要.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
传染性疾病传染性疾病

背景情况:

中性粒细胞是对抗感染的关键免疫细胞,但传统上被认为是短命和不增殖的.
限定的激活状态和快速转换是中性粒细胞特征的特性,影响它们在宿主防御中的作用.

研究的目的:

为了研究和比较肺中性粒细胞激活后感染各种病原体 (细菌,真菌,虫).
描述由虫感染引起的独特中性粒细胞反应和表型.

主要方法:

在不同病原体感染中对肺中性粒细胞激活标记物和基因表达特征进行比较分析.
在虫感染期间调查中性粒细胞死亡,增殖和IL-4R信号通路.
追踪中性粒细胞的定位和与呼吸道中的寄生虫的相互作用.

主要成果:

观察到中性粒细胞激活异质性,对细菌,真菌和虫有不同的反应.
虫感染独特地诱导了中性粒细胞中的2型反应标志物,细胞循环和蛋白质合成基因.
降低中性粒细胞死亡和增加的增殖,依赖于IL-4R信号传递,在虫感染后被注意到.

结论:

一种新的,长寿的,循环的中性粒细胞现象特点在虫感染后出现.
这种增殖中性粒细胞子集扩大,退出内皮,并准呼吸道中的虫寄生虫.
这些发现挑战了中性粒细胞作为短命细胞的传统观点,突出了它们在2型免疫中的可塑性.

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