在四个队列中,运动行为,神经运动特征和积极的音乐参与之间的多基因关联
T L Henechowicz1,2,3,4, P L Coleman3,5, D E Gustavson6
1Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto.
bioRxiv : the preprint server for biology
|April 8, 2025
概括
遗传因素影响了积极的音乐参与. 步行速度更快的遗传分数与更多的音乐活动有关,这表明运动功能和音乐参与之间有共同的遗传基础.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 音乐认知 音乐认知
背景情况:
- 积极参与音乐活动,如演奏乐器或唱歌,可能会防止与年龄相关的运动衰退.
- 音乐训练增强了感官运动技能,并改变了大脑的结构/功能.
- 运动技能和音乐参与之间的关系可能涉及共同的遗传因素.
研究的目的:
- 研究是否对运动特征的遗传倾向预测了积极的音乐参与.
- 探索运动功能和音乐参与之间的共同遗传结构.
主要方法:
- 利用全基因组关联研究 (GWAS) 的运动和大脑特征的多基因分数 (PGS).
- 分析了欧洲祖先的四个独立队列 (CLSA,WLS,BioVU,OM).
- 分析了跨队伍和音乐参与结果的PGS效应.
主要成果:
- 更快步行节奏的多基因分数与更高水平的活跃音乐参与有关.
- 在加拿大长度老龄研究 (CLSA) 中,步行速度较快的PGS预测了音乐参与度更高的几率.
结论:
- 研究结果表明,运动功能和积极的音乐参与有着共同的遗传基础.
- 未来关于音乐参与和运动功能的研究应该考虑遗传因素.
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