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Updated: May 15, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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在CRBN基板上,PCMT1产生C端周期性伊米德降解

Zhenguang Zhao, Wenqing Xu, Ethan Yang Feng

    bioRxiv : the preprint server for biology
    |April 8, 2025
    PubMed
    概括

    蛋白质碳氧甲基转移酶 (PCMT1) 通过形成C端周期性胺基来调节脑膜 (CRBN) 基质. 这一发现揭示了一条与thalidomide衍生物和CRBN功能相关的新途径.

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