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一个前额叶皮质 - 核 Accumbens 电路减轻可卡因条件下的位置偏好记忆

Xiaobo Wu^1,2, Aya M Kobeissi¹, Hannah L Phillips¹

¹Departments of Psychiatry & Behavioral Sciences and of Neuroscience and Physiology, State University of New York, Upstate Medical University, Syracuse, NY 13210.

bioRxiv : the preprint server for biology

|April 8, 2025

概括

恢复脑内皮层 (IL) 中的脑电路活动可以减少寻找可卡因的行为. 这项研究表明,可卡因使用后IL神经元功能受损的情况可以逆转,以减少与药物相关的记忆.

科学领域:

神经科学是一个神经科学.
神经生物学神经生物学神经生物学
分子精神病学分子精神病学

背景情况:

阴下 (IL) 前额皮层 (PFC) 投射到核 (NAc),并已知可以抑制药物寻找.
通过IL-NAc途径调节与药物相关的记忆的确切机制仍然不完全理解.

研究的目的:

调查IL层5神经元向NAc外 (IL-NAcSh) 投射的内在膜刺激性在抑制可卡因相关记忆中的作用.
为了确定恢复IL-NAcSh神经元刺激性是否可以减轻寻找可卡因的行为.

主要方法:

在重复接触可卡因后的动物中使用有条件的位置偏好范式.
对IL-NAcSh神经元的解剖学追踪和电生理学记录以评估膜刺激性.
化学遗传操纵以恢复IL-NAcSh神经元活动.

主要成果:

重复暴露于可卡因导致IL-NAcSh神经元激发能力的长期下降,其特征是rheobase增加,超极化和输入阻力降低.
这种低兴奋性在可卡因戒断后至少持续15天.
化学遗传恢复IL-NAcSh神经元活动成功地灭了可卡因条件下的位置偏好记忆,无论是在获取和保留期间.

结论:

IL-NAcSh电路在灭与药物相关的记忆中起着至关重要的作用.
药物损害IL-NAcSh神经元的兴奋性有助于持续寻找可卡因的行为.
恢复IL-NAcSh神经元功能提供了一种潜在的治疗策略,以减轻药物-cue关联并减少复发.

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