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下丘脑血管压缩神经元使母亲的温度调节行为成为可能

Zahra Adahman^1,2,3, Rumi Ooyama^1,2,3, Dinore B Gashi²

¹Rutgers, The State University of New Jersey, New Jersey Medical School, Department of Pharmacology, Physiology and Neuroscience, Newark, NJ, USA.

bioRxiv : the preprint server for biology

|April 8, 2025

概括

成年小鼠根据环境温度调整母乳护理,利用血管压素神经元和TRPM8热感应来保护幼. 这揭示了温度调节行为的生物机制,并可能对人类产生潜在影响.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
哺乳动物繁殖哺乳动物繁殖

背景情况:

哺乳动物新生儿通常需要父母的温度调节护理才能生存.
在小鼠中,幼的生存非常依赖于成人照顾者提供温暖和庇护,特别是在寒冷的条件下.
成年父母的照顾必须适应环境温度波动.

研究的目的:

为了研究小鼠的孕产妇护理如何适应各种环境温度.
为了识别潜在的神经机制温度依赖的孕产妇行为.
探索血管压素神经元和热感应在调节家长护理中的作用.

主要方法:

在不同温度下观察小鼠的母性行为.
测量血管压素神经元活动.
使用TRPM8热传感器操纵.
使用跨突触追踪和全脑活动映射.
特定神经通路的光遗传激活.

主要成果:

在雌性小鼠中,环境温度显著改变孕产妇的护理行为和血管压素神经元活动.
TRPM8热传感器对于温度依赖的孕产妇护理和神经活动至关重要.
副腹腔核中的血管压素神经元向参与孕产妇护理的对温度敏感的大脑区域发射.
激活向中枢桃体的血管压素投射模仿了由寒冷引起的共同育儿行为.

结论:

一个神经回路涉及血管压素神经元和TRPM8介导的热感受,调节小鼠的母体温度调节行为.
这项研究为温度依赖的家长护理提供了生物学基础.
这些发现与与环境温度变化相关的人类儿童疏忽的翻译相关.

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